Tag

Genetics

Q is for Quiz

By | A-Z

After a short break (most of the team have been off enjoying their summer holidays!) the A-Z blog is back! Since we are just over halfway through the A-Z series, Tom [EDIT Lab PhD student] has put together a quiz based on all our previous posts for you to test…

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P is for Polygenic Risk Scores

By | A-Z

Nearly all human traits, such as height, weight, and intelligence, and common disorders like major depressive and anxiety disorders are polygenic. This means that variation in more than one gene (usually many genes) contributes to total genetic predisposition for a specific trait or disorder. Chris outlines how Polygenic Risk Scores…

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N for Neuroticism

By | A-Z

Neuroticism is a personality trait characterised by easily experiencing negative emotions. This A-Z blog offers some highlights of what is currently known about the genetic and environmental influences on neuroticism, as well as its overlap with and relevance for psychiatric disorders.

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M for Missing Heritability

By | A-Z

Decades of twin studies have yielded evidence of the heritability of many different traits. What we mean by this is the proportion of variation in a trait that can be explained by genetic differences between individuals. Research has moved towards identifying specific genetic variants associated with these traits through Genome-Wide…

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K is for Kinship

By | A-Z

This week in our A-Z post for ‘K’, Tom McAdams [EDIT Lab Associate Director] outlines Kinship, a core concept in the field of behavioural genetics.

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The largest genome-wide association study of depression was published last month. What did they find and what happens next?

By | Research Matters

Depression is a leading cause of disability worldwide, contributing considerably to early mortality. Despite significant efforts, the genetics underlying depression has been difficult to identify and there has been limited progress in developing new treatments. Last month the largest genome-wide association study of depression was published in Nature Genetics (1)….

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H is for Heritability

By | A-Z

Heritability is the proportion of variation in a given population that is due to genetic differences. If a trait is highly heritable, it is more likely to be shared between individuals of close genetic relatedness, regardless of whether they share the same environment. This concept can be difficult to wrap…

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B for Biobank

By | A-Z

Next in the ‘A-Z’ series is B, for ‘Biobank’ or ‘BioResource’. Biobanks and bioresources are frequently used to support an abundance of research looking into all kinds of different disorders and phenotypes. This blog outlines exactly what a biobank and a bioresource are, and how they are used to support…

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