Mental Health

The largest genome-wide association study of depression was published last month. What did they find and what happens next?

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Depression is a leading cause of disability worldwide, contributing considerably to early mortality. Despite significant efforts, the genetics underlying depression has been difficult to identify and there has been limited progress in developing new treatments. Last month the largest genome-wide association study of depression was published in Nature Genetics (1)….

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Angry or Anxious?

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When we perceive threat, our bodies initiate a fight-or-flight response (Cannon, 1932). This physiological reaction – involving symptoms such as quickened heart rate – prepares us for action. Although unpleasant, it is likely that this adaptive response enabled our ancestors to run from or fight predators, and therefore to survive…

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E for Eating Disorders

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Eating disorders are complex, debilitating disorders which are commonly misunderstood. They are a result of complex interactions between innate biological factors (metabolism, brain reward processing in response to food), current state (adolescence, pregnancy, age) and the social environment (availability of different foods). The interactions of these factors lead to fluctuating…

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D for Depression

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Depression is the fifth leading cause of the global burden of disease and first leading mental health cause (Vos et al., 2017). Whilst everyone experiences sadness and perhaps even depression at times in their lives, perhaps following loss of a loved one, those with clinical depression experience symptoms that go…

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B for Biobank

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Next in the ‘A-Z’ series is B, for ‘Biobank’ or ‘BioResource’. Biobanks and bioresources are frequently used to support an abundance of research looking into all kinds of different disorders and phenotypes. This blog outlines exactly what a biobank and a bioresource are, and how they are used to support…

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A for Anxiety

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Welcome to the very first post of our “A-Z” series, where we will give summaries of common themes, methods, or concepts that are often mentioned or discussed on the blog. Here, we start at the beginning (which is where things normally start) with the letter A, for Anxiety. Everybody feels…

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