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Leadership Skills for Researchers: Why They Matter and How to Build Them

By King’s Careers & Employability, Careers Consultants for Researchers Team

Leadership isn’t just for people with “manager” in their job title – it’s a vital capability for anyone who wants to make their ideas a reality. For researchers, leadership is about influence, direction, and the ability to bring people and projects together to achieve impact, whether this is in or beyond academia. It also clearly demonstrates the ability to take the initiative, be innovative, take responsibility and influence others. At the end of this article we have provided a few opportunities to build your leadership skills at King’s.

Why develop leadership skills?

Research increasingly depends on collaboration, whether in interdisciplinary projects, supervising students, coordinating with industry or policy partners and to secure research funding. Strong leadership helps you motivate others, make sound decisions, and communicate a clear vision – qualities that shape not only successful research teams but also resilient, innovative careers more broadly.

In many fellowship applications this is reflected in the narrative CV under the heading that is usually something like ‘Development of others and maintenance of effective working relationships’ where you can demonstrate your research leadership capability through leading a team, collaborators, partnerships and/or networks.

Leadership is one of the most frequently mentioned skills in UK job adverts and came under the broader cluster of ‘strategic management and governance’ as found by research led by Imperial that analysed over 65 million UK job adverts. The World Economic Forum lists leadership and social influence among the fastest-growing skills across all sectors which is no surprise when you consider that this is probably the most important skill for employees dealing with and supporting others with change. Whether you aim for a lectureship, a policy post, or an R&D role in industry, developing leadership skills makes you more adaptable and employable.

What’s the benefit?

Leadership skills translate directly into effectiveness at work: you’ll manage time and resources better, foster inclusive collaboration, and be able to guide teams through uncertainty – a daily reality in the current workplace. They also enhance your confidence in influencing upwards (for example, when negotiating project scope or impact) and sideways (when coordinating across disciplines or institutions).

Crucially, leadership development supports wellbeing. Knowing how to delegate, give feedback, and handle conflict has been linked to reducing burnout and creating healthier research and work cultures.

How can I develop leadership skills?

  • Start small: Lead a project meeting, coordinate a reading group, or supervise an undergraduate project. Every opportunity to guide others builds experience.
  • Seek feedback: Ask colleagues and supervisors for feedback on your communication and decision-making style.
  • Learn formally: King’s offers short courses including research leadership and project management and you also have access to LinkedIn Learning
  • Observe and reflect: Notice how effective leaders around you handle challenges and motivation.
  • Look beyond academia: Volunteering, community projects, meaningful work experience opportunities and entrepreneurship all provide ways to practise leadership.

Leadership is often one of the skills that is most highly rated by academia and industry for your future roles yet it is seldom formally taught during a PhD. Our recent ‘Careers in your Ears’ podcast episode with Dr. Matthew Betts talks about exactly this and recommends being proactive and speaking to your supervisors or other academics about the kind of leadership skills that are required.

Acquiring leadership skills is something you can do to prepare for your next career stage and you may also discover new interests and connections along the way.

Leadership development opportunities at King’s include:

  • King’s Careers & Employability’s Insights Programme: three week virtual consultancy project
  • King’s Entrepreneurship Institute: training and development opportunities for doctoral researchers
  • King’s Doctoral College: variety of training opportunities including “The Leading Researcher: What is your leadership style and how can you enhance your influence?” Friday 12 December, 09:30-12:45, online – Visit SkillsForge (PGR323) to find out more and to book your place.
  • King’s Doctoral College Community Wellbeing Fund: bid for funding and lead your own project to build your doctoral community
  • KDSA: There are a couple of roles remaining for doctoral representatives on the King’s Doctoral Student Association including: part-time PGRs, healthcare professionals, NMES faculty, KBS faculty, Guys campus, Francis Crick. Email kdsa@kclsu.org if interested.

Find out more about our careers support for researchers at King’s including our podcast Careers in Your Ears, one-to-one appointments, online resources and a variety of workshops and events.

King’s Outstanding Thesis Prize Winners 2025

King’s Outstanding Thesis Prize Winners 2025

Each year the King’s Doctoral College gives out a limited number of awards to celebrate truly outstanding research and theses completed by King’s doctoral students.

The King’s Outstanding Thesis Prize Winners receive their awards at their graduation ceremony and also receive a £250 prize.

The Winners of the Second Round are:

Luke Vano, Institute of Psychiatry, Psychology & Neuroscience

“Multimodal Imaging Links Elevated Striatal Dopamine Synthesis in Schizophrenia with High Neuromelanin and Brain Iron Deficiency.”

Luke Vano

Luke Vano

I am deeply honoured to have been awarded a King’s Outstanding Thesis Prize. I joined the Maudsley Psychiatry Training Programme with the ambition of contributing to cutting-edge research. After many unanswered emails to prospective supervisors, I began to think it might not be possible—until I attended a lecture by Oliver Howes on the biological basis of schizophrenia. Captivated by his insights, I reached out, and he responded. Since then, Oliver has been an exceptional mentor, providing constant support and guidance. I am also grateful to Ian Everall, whose encouragement and inspiration have been invaluable throughout my research journey.

My PhD investigated how changes in brain iron and neuromelanin—a product of dopamine metabolism—relate to dopamine dysfunction in schizophrenia. Using MRI and PET imaging, I provided evidence that patients with schizophrenia have higher neuromelanin levels but lower brain iron compared to healthy controls, and that these changes are linked to elevated dopamine synthesis. The findings suggest that disruptions in iron homeostasis and neuromelanin production contribute to striatal hyperdopaminergia in schizophrenia—a hallmark of the disorder. Investigating the origin of these abnormalities may offer new biomarkers and treatment targets.

The analysis pipelines developed for this thesis are rooted on the pioneering work of Robert McCutcheon. His ability to demystify the most complex topics has often left me in awe. I feel incredibly fortunate to have had him as a supervisor. I am also indebted to Jan Sedlacik, Stephen Kaar, Grazia Rutigliano, and Mattia Veronese for their guidance and for making my time in research so enjoyable.

I am currently continuing my research at King’s as a postdoctoral researcher, alongside continuing my psychiatry training. 

Find out more about Luke’s postdoctoral research on LinkedIn.

Yong Li, Faculty of Life Sciences & Medicine

“Novel methods for estimating (poly)phenol consumption: relationship with cardiometabolic health.”

Yong Li

Yong Li

It is with immense pride and gratitude that I accept the King’s Outstanding Thesis Prize. My academic journey began in China with a BSc in Food Quality and Safety at Nanjing Agricultural University, followed by an MSc in Nutrition and Food Hygiene at Peking University, where I graduated among the top of the department and developed a strong foundation in public health nutrition, epidemiology, and experimental research. I also actively engaged in public health outreach—founding a OneHealth student society, coordinating cross-national academic workshops, and participating in HIV prevention campaigns, which cultivated my commitment to translating scientific insight into public benefit. 

During my PhD at King’s, I pioneered novel methodological approaches to assess (poly)phenol intake and its role in cardiometabolic health. I developed the King’s College London (Poly)phenol Food Frequency Questionnaire, a (poly)phenol-rich dietary score, and a corresponding metabolic signature, which were all applied to the TwinsUK cohort (n = 3110). This work revealed significant inverse associations between adherence to (poly)phenol-rich diets and cardiovascular risk scores, contributing meaningful tools to nutritional epidemiology. The work led to 13 publications with 10 as first author (including 2 under-review) in leading international journals, along with 18 abstracts presented and 7 oral presentations at prestigious international conferences, and five awards, competitive travel and registration grants. I was also selected as a finalist in the Biological and Biomedical Sciences category at STEM for BRITAIN 2024, where I presented my research to MPs at the Houses of Parliament, which allowed me to discuss the public health relevance and methodological contributions of my work directly with policymakers. 

Moving forward, I will continue my academic path and further apply the tools developed during my PhD. I also look forward to completing several publications and pursuing new collaborations in nutrition and public health. 

Thanks again for this incredible recognition.

You can discover more about Yong Li’s work on LinkedIn and Twitter: @YongLi35986394

Guiming Han, King’s Business School

“Shocks, Budget Stickiness, and Network Effects in Retail Investor Decision-Making.

Guiming Han

Guiming Han

I am honoured to have received the 2024/25 King’s Outstanding Thesis Prize. I am deeply grateful to my supervisors, Professor Alex Preda and Dr Filippos Papakonstantinou, as well as my colleagues and friends at King’s, for their guidance and encouragement throughout my doctoral journey. 

Before starting my PhD, I graduated with distinction in MSc Corporate Finance at King’s Business School and gained professional experience in investment analysis and project management in Shanghai. These experiences provided a strong foundation in both practice and theory, motivating me to return to King’s to pursue a doctorate in Finance. 

My thesis consists of three essays in empirical finance that explore how trader behaviour shapes investment decisions and outcomes. The first investigates how risk preferences shift after trading shocks, uncovering asymmetric behavioural responses between small and large shocks. The second introduces the concept of budget stickiness, showing that adherence to pre-set budgets fosters more disciplined trading and better performance. The third examines status competition in online social trading platforms, highlighting how network initiation informally regulates competition. Collectively, the thesis advances our understanding of risk, financial personality traits, and social dynamics in markets. 

Looking ahead, I plan to continue an academic career, extending my research on behavioural finance, networks, and the digital economy, with the aim of contributing to both scholarly debates and policy-relevant insights. 

If you’d like to find out more about Guiming’s current research, then please check out his LinkedIn page. 

Eleanor Gluck, Faculty of Arts & Humanities

“Relational and Strange: A Queer Reading of Aury, Bataille and Sade in Translation.”

Eleanor Gluck

Eleanor Gluck

Following my undergraduate degree at the University of Glasgow, having spent a year living and working in Toulouse, I returned to South Wales, where I grew up, to study for a Masters in Translation at the University of Swansea. This was made possible thanks to a grant and funding from the Welsh government. Though the MA was concerned primarily with the practicalities of technical translation, I grew increasingly interested in the theoretical and practical delicacies of translating literature, specifically as it involves the re-writing of gender, sexuality, and sex.  

The work of William Spurlin was a major source of inspiration, motivating the pursuit of a PhD. It was, then, for me, a full circle moment to have the opportunity not only to meet William but have him be one of my examiners. The viva turned out to be – thanks to William and Elliott Evans (who, as it turns out, in another full circle moment, went to the same comprehensive school in South Wales as me) – a humbling and joyous experience.  

Over the course of my PhD, I became a mother to my daughter Mabli. I have been supported immeasurably over the course of it by my partner Tom, as well as friends, family, and, especially, our daughter’s childminders. Finally, in the first place, this PhD would never have been remotely possible without my supervisor Ros Murray who championed it from the start and was a steadfast source of courage, inspiration, and friendship. I left every meeting with Ros buoyed.  

Since completing my PhD I have been working on getting my thesis published as a monograph, while, until recently, being a full-time mum. I am not entirely sure what the future holds but I am very grateful to have been able to complete this PhD thanks to funding from LAHP. To receive this award is surreal, and I am very grateful.  

You can connect with Eleanor on LinkedIn

Uxio Hermida Nunes, Faculty of Life Sciences & Medicine

“Computational Approaches to Unveil the Hidden Fetal Arch Shape and Flow Signatures in Coarctation of the Aorta.”

Uxio Hermida Nunes

Uxio Hermida Nunes

I completed my BSc in Biomedical Engineering at Universitat Pompeu Fabra (UPF) in Barcelona, where I first became interested in cardiac modelling and how computational simulations can help us better understand cardiac disease. During my final year, I joined Philips Research Paris for an internship, working on simulations of cardiac valves using numerical methods. I then moved to London for an MSc in Healthcare Technologies. After a successful MSc project with Professor Pablo Lamata, I began my PhD journey under the supervision of Professor Lamata and Dr Adelaide De Vecchi.

My doctoral research focused on developing computational approaches to study fetal aortic arch morphology and haemodynamics in cases of coarctation of the aorta using novel fetal magnetic resonance imaging. This work was made possible through a close collaboration with the clinical team at St. Thomas’ Hospital (Dr Milou Van Poppel, Dr David Lloyd and Dr Kuberan Pushparajah). Working within this multidisciplinary environment of engineers and clinicians was deeply rewarding and reinforced my belief in the power of collaboration for clinical impact.

Throughout my PhD, I presented my work at international conferences, published in journals, and was nominated as Best Postgraduate Researcher by the School of Biomedical Engineering and Imaging Sciences. I also represented King’s at the STEM4Britain competition at the UK Parliament and won the HS-DTC Best Scientific Image Award.

After completing my PhD, I moved to Paris to join Dassault Systèmes as a Research Engineer in the MEDITWIN project, developing digital twin technologies for paediatric cardiology. This role allows me to continue pursuing my passion for computational modelling and digital twins in paediatric and fetal cardiology.

Receiving the King’s Outstanding Thesis Prize is an honour and a meaningful recognition of this journey. I’m deeply grateful to my supervisors, Professor Pablo Lamata and Dr Adelaide De Vecchi, for their guidance, encouragement, and for fostering such a collaborative and inspiring research environment.

Check out Uxio’s research profile on Google Scholar and connect on LinkedIn.

Ilaria Di Dedda, Faculty of Natural, Mathematical & Engineering Sciences

“Type A symplectic Auslander-Reiten theory”

Ilaria Di Dedda

I am honoured to have been awarded one of the King’s Outstanding Thesis Prizes. I am grateful to my supervisors Professor Yankı Lekili and Professor Konni Rietsch, and to my peers and colleagues for their steady support throughout my PhD. I would also like to thank my examiners and the panel for this recognition.

I came to King’s to study for my MSc in Mathematics, after completing a BSc at the Università degli Studi di Torino, Italy. I enjoyed my course, but above everything I loved working on my MSc Final Project, which gave me a first taste of what research in Maths looked like, and which pushed me to pursue a PhD. My PhD thesis studies interactions between symplectic geometry and representation theory, two fertile areas of Mathematics, concerned with the study of both abstract and physical objects. Each area has its own individual set of problems and open questions, which researchers in the respective fields tackle every day, but it is often thanks to these unexpected connections that we are able to find new answers to them.

During my PhD, I have presented my research at international conferences and seminars, my work has been accepted for publication, I was the co-winner of the third year “PGR research competition” prize (2023), and I have been nominated for an Outstanding Teaching Assistant (2022) and a King’s Education Award (2023). I am especially pleased to be receiving this Prize after being awarded the equivalent one for my MSc Project in 2019, also under the supervision of Professor Lekili, which makes me feel like my experience at King’s has come full circle.

I am now fortunate to have a postdoc position at the University of Edinburgh, where I am looking forward to work on new research problems.

You can read more on Ilaria’s Google Page.

Victoria Charlton, Faculty of Social Science & Public Policy

“To what extent can NICE defend its claim to be an ethical priority setter?”

Victoria Charlton

Victoria Charlton

I am honoured to receive a King’s Outstanding Thesis Prize. I would like to sincerely thank my examiners, supervisors, and the panel for this recognition.

My decision to do a PhD came as a surprise to many – not least me – as at the time I’d been working for several years in science policy, first as a Specialist to the House of Commons Science and Technology Select Committee and later as Head of Policy at the Academy of Medical Sciences. (In my opinion, the best job in the world). But having decided to start a family, my hormone-addled brain thought that part-time doctoral study would be the perfect way to balance flexible working with looking after young children. Nine years on, that decision has paid off and this wonderful prize is further endorsement of a journey that hasn’t always been easy.

I’ve always been fascinated by ethics and was interested in the role that ethical considerations play in shaping – or failing to shape – public policy. And nowhere are the ethical implications of policy decisions more salient than in the arena of healthcare priority-setting. My thesis combines empirical research with ethical analysis to explore the role that normative (that is, value-based) commitments play in shaping the priority-setting decisions reached by the UK’s National Institute for Health and Care Excellence (NICE). It finds that though many of the values underpinning NICE’s formal approach are highly coherent and support NICE’s main goal of promoting population health, coherence is sometimes lost in the translation of this approach into real-world decision-making. In a nutshell, though NICE claims to act ethically in making decisions about which new drugs NHS patients should be able to access, my research suggests that this claim cannot be robustly defended.

Since completing my PhD, I have taken some time to consider what comes next. The challenge of combining work with childcare does not, as it turns out, end once the kids are in school so my current plan is to continue working in academia part-time while also embarking on other pursuits. As such, I have recently taken up a position as a Visiting Research Fellow at LSE Health while continuing to publish and teach regularly at Imperial College London – a portfolio of roles that, in general, means that I’m still available for pick-up at 3.30pm.

Read more about Victoria’s research on her King’s Profile.

Francesca Ideo, Faculty of Dentistry, Oral & Craniofacial Sciences

“Apical periodontitis and immune system:Influence of patient’s immunomodulation on endodontic disease.”
Francesca Ideo

Francesca Ideo

It was truly an honour to be a student at King’s College London.

I was an off-site PhD student, as I live in Cagliari, a beautiful city in Sardinia, in the south of Italy. 

My career in dentistry began with Dental degree in 2013 at the Universitiy of Cagliari, Italy, where I also completed a master’s degree in Clinical and Surgical Endodontics in 2016. 

My research stemmed from my long-standing work at the University Hospital of Cagliari. Over the years, I have been involved there first as a student, then as a clinical trainer, and now as a health professional. Being in close contact with patients affected by various conditions and under different treatments helped me realise how deeply systemic and oral health are interconnected. This awareness inspired the topic of my PhD thesis

I mostly focused on finding a connection between autoimmune-diseases and medications taken by the patients to treat these conditions (immune-modulators and immnune-suppressant drugs) and the prevalence and healing of apical periodontitis, one of the most frequent oral disease in the world. 

Throughout my PhD, I received support and guidance from Professor Francesco Mannocci and Professor Elisabetta Cotti, to whom I owe my heartfelt gratitude.

During this time, I had the pleasure of presenting my project several times at international conferences, where I met many researchers who showed great interest in my work, and I received an award for the best clinical research from the Journal of Endodontics in 2023.

Pursuing this  PhD gave me the opportunity to deepen my knowledge and to work with patients who needed care with greater understanding and scientific awareness.

Now that I have completed my PhD, I am working as an adjunct professor at the University of Cagliari, and I sincerely hope to maintain a strong connection with King’s College.

Studying there has been one of the most enriching and inspiring experiences of my life.

Find out more about Francesca’s research on ResearchGate.

Hannah Scott, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care

Hannah Scott

Hannah Scott

“Developing an implementation plan with theoretically-informed strategies for integration of the Children’s Palliative care Outcome Scale into routine paediatric palliative care.”

I am delighted to have received an Outstanding Thesis Prize. I would like to thank my supervisors, Professor Richard Harding, Dr Claire Ellis-Smith, and Dr Debbie Braybrook for their support throughout the process, my examiners, Professor Ulrika Kreicbergs and Professor Bernie Carter for nominating me for this award, and to the NHIR ARC South London for funding my PhD.

I started working on the Children’s Palliative care Outcome Scale (C-POS) study as a research assistant in 2020 as my first full-time research job after having completed an MSc in Social Policy and Social Research (University College London) and BA(Hons) Children, Young People, and Families (York St John University). I knew at this point I wanted to pursue a career in research and at some point, do a PhD. Within my first year, Professor Richard Harding identified an NIHR ARC South London studentship and encouraged me to apply to undertake a PhD as part of the wider study. 

For my PhD, I developed an implementation plan that will be able to support the integration of C-POS into routine hospital-based care for children with life-limiting and life-threatening conditions. I was also able to apply for a Seedcorn grant from the Faculty of Nursing, Midwifery, and Palliative Care to develop short videos for parents  and professionals to communicate the anticipated benefits of the tool and further support future implementation.

I also had the opportunity to present my work at several international conferences, including the European Association for Palliative Care 12th World Congress, where my poster on ‘Challenges and incentives for integrating person-centred outcome measures into routine paediatric palliative care: health, social care, and commissioner perspectives’ won an award for one of five best posters in category.

Since completing my PhD, I have been working as a research associate, at Queen Mary University of London, on studies focused on the impact of science communication events for families affected by multiple sclerosis and understanding what matters most to children with dystonia and their families.

Find out more Hannah’s research via ORCiD, LinkedIn, BlueSky and Twitter

Joanne McDermid, Institute of Psychiatry, Psychology & Neuroscience

“Randomised Controlled Trial of the iWHELD Programme: A Novel Digital Non-Pharmacological Intervention to Improve Quality of Life in People Living with Dementia in Care Homes.”

Joanne McDermid

Joanne McDermid

I’m so happy and honoured to have received the King’s Outstanding Thesis Prize. Completing my PhD part-time at King’s College London was an incredible journey, and I’m thrilled to have my work recognised in this way.

My research focused on developing and evaluating a novel digital training programme to improve quality of life for people living with dementia in care homes. This included leading two randomised controlled trials, one involving over 600 participants and delivered during the height of the COVID-19 pandemic. The programme demonstrated significant impact in enhancing wellbeing and reducing the use of psychotropic medication.

The research resulted in multiple peer-reviewed publications, including in a leading dementia journal, and was recommended for national implementation in an Alzheimer’s Society report to government. I also secured postdoctoral funding to support further real-world evaluation.

Alongside my academic journey, I navigated two periods of maternity leave, including a twin pregnancy, and have been raising my three little girls alongside completing the PhD. It was a demanding but deeply rewarding experience that taught me a great deal about resilience, staying focussed on my purpose, and holding onto a long-term vision. 

Since completing my doctorate, I’ve continued in applied dementia research, with a growing focus on real world implementation and closing the gap between evidence-based research and everyday practice. I’m particularly interested in how we create digital, human-centred tools that are genuinely built for real life and real challenges, and exploring how emerging technologies, such as AI, can enhance care and deliver meaningful support at scale, without losing what matters most: human connection.

About the prize

The prizes are nominated by the external examiners and are judged by a panel consisting of the College’s Director of Research Talent and the Chair of the Research Degrees Examinations Board. There are two rounds, in January and June, and these are the winners from the second round.

HSDTC Science Communication Competition Entries II 2025

Following on from last blog, we continue to share entries from the HSDTC Science Communication Competition, where doctoral researchers in the four Health Faculties showcase their work in engaging newspaper-style articles.

 

Li Ling, Faculty of Natural, Mathematical & Engineering Sciences, Informatics

New tool spots hidden patterns in massive datasets — in minutes

A powerful new data-mining tool developed at King’s College London can analyse hundreds of millions of data points and detect patterns in less than 20 minutes—something that could take existing systems over a day.

From identifying patient groups based on heart readings to tracking whale calls underwater, this breakthrough could transform how we make sense of massive datasets in medicine, transport, finance, and more.

The key lies in its clever design. While many current algorithms slowly scan through data line by line, this tool builds a special structure—like an index—so it can jump directly to where patterns hide. This structure can be reused to uncover different types of trends quickly and with minimal memory, even across massive datasets.

“When analysing underwater recordings, our tool found hidden patterns in dolphin and whale sounds in just 18 minutes,” said Ms Ling Li, a PhD student who worked on the project. “Other tools failed to finish even after 24 hours.”

It’s already making waves in medicine. In a study using heart monitor data, the tool discovered two distinct groups of people: those who experienced exercise-related pain and those who didn’t. The patterns revealed that more active individuals reported more pain—a finding that could help tailor exercise plans.

The team is now extending the tool to other medical data, such as sleep studies. They also plan to make the tool context-aware, so it not only finds patterns but helps explain what they mean—vital for applications in bioinformatics and beyond.

This tool shows how smart data handling can unlock insights hidden in plain sight—and fast.

Martina Galea Mifsud, Faculty of Dentistry, Oral & Craniofacial Sciences, Centre for Oral, Clinical and Translational Sciences

Revolutionising bone grafts: PEEK scaffolds offer new hope for patients

A groundbreaking development in bone reconstruction could soon transform the way we treat patients with cancer. A researcher at King’s College London is exploring the potential of the advanced biomaterial polyetheretherketone, in short PEEK, scaffolds for use in bone grafting.

PEEK, which is a synthetic polymer with incredible physical and chemical properties, has long been used in medical implants thanks to its strength, durability and biocompatibility. Now, scientists are pushing its boundaries by creating scaffolds which mimic the natural structure of bone – solid from the outside and porous from the inside. These scaffolds act as permanent frameworks to guide new bone growth and integrate within the body, in a process which scientists call ‘osseointegration’. Once they are part of the patient’s body, they are there for life!

A main driving force behind this research is the need for improved solutions for patients who need to undergo any form of bone reconstruction, but especially those needing maxillofacial reconstruction. This is because currently, a patient would need to have secondary surgery on their leg (namely, the fibula bone) to harvest bone to be used for reconstruction of facial defects – making this process invasive, painful, and frankly – unnecessary. The PEEK scaffolds being created in this study not only offer the traditional physical and chemical benefits, but also have the added feature of actively integrating within the bone biologically, something which there is currently very little research about!

“We want to offer alternative solutions to our patients, removing the need for additional surgery”; Martina Galea Mifsud; primary researcher and Maxillofacial Prosthetist says. “PEEK has the potential for exactly this. In the future, the scaffold can also be [3D] printed with dimensions tailored to each individual patient, marking a shift in outdated practices which have been used for decades”.

The research aims to not only fabricate the scaffolds, but also modify with a natural chemical called ‘peptide’, which would allow the human body to integrate this scaffold. This pioneering work could soon pave the way for a new era in bone regeneration, where science and technology converge to rebuild lives, one patient at a time.

Mrinalini Dey, Faculty of Life Sciences & Medicine, Inflammation Biology

From blah blah to aha! Making health make sense

When did you last speak to a health professional?

Perhaps you were receiving a new medication. Perhaps you were getting vaccinated. Perhaps you were having a test.

Did you understand all the information you received?

If not, you are not alone.

Seven million adults in the UK read at or below the level of a nine-year-old. This has profound consequences, especially when it comes to health materials, which can be complex and full of jargon. Almost half of all adults struggle to understand information which could help them to manage their own health.

Health literacy is the “ability to gain access to, understand and use information to maintain good health.” Limited health literacy has been linked to poor health outcomes, including increased hospital admissions, low use of preventative services (such as vaccination and screening) and reduced life expectancy.

More people are living with chronic conditions, such as diabetes and heart disease. Rheumatic diseases are complex chronic conditions, due to overactivity of the immune system. These affect the joints, as well as other organs such as the skin and lungs. Examples include rheumatoid arthritis and lupus. Increasing evidence demonstrates socioeconomic factors, such as deprivation, greatly influence the health experience of people living with rheumatic diseases. However, until now, few to no studies have investigated the importance of health literacy in people living with these, often debilitating, conditions.

Through assessing health literacy in a thousand people with rheumatic diseases across the UK, we have shown that low health literacy is associated with having more joint symptoms such as pain, decreased likelihood of employment and attendance at work, and a greater number of co-existing health conditions, such as diabetes and high blood pressure.

It is time to reverse the health literacy epidemic. Only through understanding the impact of health literacy on people’s lives and health can we develop interventions which enable treatment plans to be tailored to an individual’s health literacy needs.

In doing so, we will empower people to take control of their health, make health-related decisions, and have the confidence to discuss these with their doctor and wider healthcare teams.

Syed Alhafiz Bin Syed Hashim, Faculty of Life Sciences & Medicine, Institute of Pharmaceutical Science

Breaking through the dark magic: Reprogramming cancer’s defences

Cancer remains one of the world’s greatest health challenges, and despite decades of research, many patients still face tough odds. A key reason is that tumours do not grow in isolation. They are surrounded by a complex mix of cells, blood vessels, and immune components that protect them. Imagine the tumour as Voldemort, shielded by layers of dark magic and enchanted defences. These biological barriers are like protective spells that help the cancer resist treatment. Just as Voldemort uses his magic to survive and grow stronger, the tumour’s environment protects the cancer, making it harder for chemotherapy and the immune system to reach and destroy it.

At King’s College London, a team led by Professor Al Jamal is working to change this. Syed Alhafiz, a PhD researcher, is exploring a promising new therapy for an aggressive form of breast cancer that resists traditional treatments. This cancer does not respond well to some therapies and is difficult to target with chemotherapy. His research focuses on tiny lipid carriers that deliver chemotherapy directly to cancer cells while sparing healthy tissue. These carriers are like Harry Potter’s magical tools, smart, selective, and precise, able to slip past the tumour’s barriers and strike the true target.

The team is also investigating how these lipid carriers might alter the tumour’s environment. By weakening the tumour’s defences, they make it more vulnerable to treatment and help the immune system fight back. This mirrors how Harry and his allies worked to dismantle Voldemort’s protections and expose his weaknesses. This work is not limited to breast cancer alone. Similar methods are being applied to target brain cancer, as well as diseases that affect the nervous system, such as ALS, which weakens muscles and nerves.

Like the final battle between good and evil, this research aims to tip the balance in favour of the body. By reprogramming the tumour’s environment, this approach may enhance treatment effectiveness and reduce harm to healthy cells, offering new hope for more precise and powerful cancer care.

Yujia Yang, Faculty of Life Sciences & Medicine, School of Cardiovascular and Metabolic Medicine & Sciences

From stress to peace: Early detection of a silent killer (Ishaemic Heart Disease)

Imagine being told to sprint on a treadmill or ride a bicycle while your heart is monitored for signs of disease. For many patients—especially the elderly or those with limited mobility—this so-called “stress echocardiography” feels more like a stress ordeal.

But researchers at King’s College London may have found a better way—a more peaceful solution.

They’ve developed a promising new measure of heart function called First-Phase Ejection Fraction (EF1), which could detect heart disease earlier—and far less stressfully—than traditional methods.

Ischaemic heart disease (IHD), a silent killer caused by narrowed or blocked arteries, can often lead to chest pain, heart attacks, or heart failure. The earlier it’s caught, the better the chances of prevention.

Since most people with IHD don’t show symptoms or signs of abnormalities at rest, their heart has to be put under “stress”—through exercise or medication—to reveal the problem. But not everyone can manage this “stress.” Patients often describe it as a “torturing chamber”—exhausting, and sometimes the results are inconclusive if they cannot achieve the required amount of exercise. Therefore, a more peaceful and smarter solution is needed.

EF1 works differently. It measures the heart’s initial contraction—a key early signal of dysfunction—using a standard ultrasound scan (echocardiography). No treadmill, no drugs, no stress.

First introduced in 2017, EF1 has already shown promise in detecting many common conditions, such as high blood pressure and complications from COVID-19. With the help of artificial intelligence, it could soon become even more accurate and accessible.

Better for Patients—and the NHS

Stress echocardiography costs the NHS about £340 per patient, while EF1, which can be measured during a routine ultrasound, costs just £120—and is easier to perform across a wider range of patients.

That’s why EF1 is being trialed in the EVAREST study, involving over 8,000 NHS patients who underwent stress echocardiography nationwide. Upon completion of this study, we aim to provide a faster, cheaper, and—more importantly—a peaceful way to diagnose IHD before it becomes life-threatening.

Early detection saves lives. With tools like EF1, the future of cardiac care could be more accessible—and far less stressful—for patients everywhere.

HSDTC Science Communication Competition Entries I 2025

HSDTC Science Communication Competition Entries I 2025

Are you interested in reading about more exciting health research happening at King’s? In this blog, we continue to share entries from the HSDTC Science Communication Competition, where doctoral researchers in the four Health Faculties showcase their work in engaging newspaper-style articles.

Anna Davison (Collini), Faculty of Life Sciences & Medicine, Centre for Education

Medical students face burnout crisis: New research searches for solutions

Burnout and emotional distress exist at worrying levels among medical students and doctors, with the General Medical Council recently finding over half of doctors in the United Kingdom are at risk. This troubling trend not only affects the well-being of future doctors but also has serious implications for patient care and retention within the profession. Higher levels of burnout among doctors can lead to increased medical errors, decreased patient satisfaction, and may also be contributing to the medical workforce shortage with burnout being a common cause for leaving the profession.

While burnout can result from various work-related stresses, research indicates that perfectionism and imposter syndrome may play an important role. Both involve relentless comparisons to unrealistic ideals, causing distress and feelings of shame. With the competitive and rigorous training that future doctors undergo, high expectations are unsurprising. However, some of the ideals ingrained in medical culture may be harmful – as a medic, feeling they must be perfect can lead to hiding mistakes, suppressing emotions may decrease the empathy they have for patients, and seeing illness as weakness can prevent seeking help for themselves.

Other ideals may relate to aspects of identity, with those differing from the traditional white, male, able-bodied, heterosexual, middle-class doctor particularly vulnerable to imposter syndrome and shame. These individuals can feel pressured to change who they are to fit into an outdated professional mould.

To address this critical issue, a new study is exploring these professional ideals – investigating what they are, where they come from, and how they interact with the personal identities of individuals. The research will use observations, interviews, diaries, and relevant documents to go beyond individual experience and examine the broader culture of medicine in which a professional identity is formed.

The implications for medical schools are profound. This research will help educational institutions to reevaluate their environments to ensure inclusive settings where students can develop balanced and realistic professional ideals, with the aim of mitigating burnout. Crucially, these ideals should uphold high standards without requiring students to compromise who they are, ultimately benefiting both medics and patients alike.

Charel Junior Mangama Sindzi, Faculty of Life Sciences & Medicine, School of Biomedical Engineering & Imaging Sciences

MRI for the masses: Paving the path to global cardiovascular care

In 2021, the Institute for Health Metrics and Evaluation (IHME) reported 19.41 million deaths (29% of global mortality) from cardiovascular diseases, making them the leading global cause of death.  Cardiovascular diseases, which encompass conditions affecting the heart and blood vessels, include cardiomyopathies—disorders that affect the heart muscle. These conditions often lead to changes in the heart’s structure, such as thickened, stiffened, or stretched walls, impairing the heart’s ability to circulate blood effectively.

 

To help with early detection of health conditions, imaging modalities such as Magnetic Resonance Imaging (MRI) are commonly used. MRI is a non-invasive technology used to obtain detailed anatomical scans of the heart. Unlike some of its counterparts (X-rays, CT, PET), MRI does not use ionizing radiation and provides great soft tissue contrast. Additionally, thanks to quantitative MRI, an accurate and precise diagnosis can be made. This makes MRI the perfect imaging modality to fight back against the cardiovascular death rate.

While most clinical MRI scanners operate at higher magnetic fields (1.5T or 3T), these systems are expensive, limiting their availability in low- and middle-income countries (LMICs). Low-field MRI systems, like the Siemens MAGNETOM Free. Max (0.55T), provide a more affordable alternative, offering reduced production costs, compact size, and improved patient comfort.

The existence of such scanners is a game-changer towards the widespread use of MRI throughout the world, especially in economically disadvantaged regions. However, to provide the same quality of service as with higher fields, lower-field systems require the development and implementation of tailored techniques to ensure accurate, reliable, and reproducible results.

To achieve this wider goal, my PhD project has been undertaken.

My research focuses on developing new MRI pulse sequences, series of instructions based on physics-based and computational innovation, to allow those lower-field systems to produce MRI quantitative cardiac maps which can rival those of higher-field systems.

A global widespread of MRI systems is possible, thanks to the affordability of the lower-field systems, and the competitive MRI pulse sequences made through this PhD project. We would be one step closer to accessible healthcare and global early detection of cardiovascular diseases.

John Makanjuola, Faculty of Dentistry, Oral & Craniofacial Sciences, Centre for Oral, Clinical & Translational Sciences

Smart innovative dental materials: Your secret weapons against tooth decay!

Tooth decay is a silent epidemic that affects billions worldwide, yet it is often overlooked. The World Health Organization has consistently reported tooth decay as the most prevalent chronic disease globally. It affects a staggering one in four children and one in three adults in the UK, resulting in painful toothaches and negatively impacting overall health. The financial toll on the NHS in treating affected patients exceeds £3 billion annually. With the British government considering cost-cutting measures amidst rising healthcare expenses, the spotlight is now on innovative solutions to tackle this pressing problem.

Traditional silver amalgam, used as fillings for decayed teeth, contains toxic mercury that has raised significant health and environmental concerns. Thus, prompting calls for a ban by 2030. To address this issue, researchers are now focusing on dental composites. However, composites are unable to combat decay-causing bacteria and frequently fall short when used in vulnerable groups, including children, seniors, individuals with disabilities, and underserved communities. The groundbreaking development of “smart” materials is transforming dental care, offering innovative solutions that significantly differ from conventional tooth-filling materials.

In the quest for an effective replacement for mercury-based fillings, my PhD research made significant strides by developing a cutting-edge “smart” material—bioactive glass-ionomer material containing magnesium and zinc, using a precisely balanced formulation. Developed in laboratory conditions that replicate the human mouth, this revolutionary material mimics natural teeth while actively combating decay. It forms a protective, mineralised layer on the tooth and releases therapeutic agents, including magnesium and zinc, that effectively combat tooth decay. Extensive tests have demonstrated that this new material not only enhances strength properties but also exhibits excellent antibacterial activity compared to currently available tooth-filling materials. This makes it a strong candidate for future use in dentistry. With rigorous safety testing confirming its suitability for human use, this innovative material is poised to enter clinical trials. As we approach the 2030 deadline for phasing out mercury-based fillings, this “smart” filling could revolutionise dental care, offering hope for improved dental health outcomes—especially for underserved populations. A brighter, healthier future for oral health may be just around the corner.

Lauren Woodcock, Faculty of Life Sciences & Medicine, Analytical, Environmental and Forensic Sciences

The true scale of illegal pangolin poaching

We need to talk about pangolin poaching. An estimated 2.7 million pangolins are poached (illegally killed or trafficked) yearly for their scales, which is equivalent to the entire population of Qatar. The annual revenue of pangolin poaching is approximately $23 billion. I am a forensics researcher, specifically obtaining fingermark evidence from the surfaces of pangolin scales. Scales are illegally acquired and sold for use in traditional Chinese medicine to “cure” numerous ailments, although there is no evidence to suggest that they have any healing properties. I aim to educate on the true “scale” of pangolin poaching.

The ramifications of poaching extend far beyond a decline in animal welfare. The illegal transfer of live animals and wildlife goods can facilitate the spread of zoonotic disease: a famous example of this being the 2003 SARS pandemic. Poaching leads to a decline in biodiversity, human injury, and cultural loss. Lucrative organised crime syndicates profit by exploiting wildlife, though other types of crimes are often associated with these syndicates, such as money laundering, complex fraud, gun crime and corruption. Profits gained through illegal wildlife trafficking are funnelled back into other types of organised crime, funding a billion-dollar black market industry.

I visualise fingermark ridge detail on pangolin scales using traditional forensic techniques. Some of these techniques involve the application of fingerprint powders and fluorescent dyes, superglue fuming and the vaporisation of metals like gold and zinc to visualise high quality ridge detail on pangolin scales. The techniques I refine and validate will be used by forensic practitioners on wildlife crime scenes and police laboratories. Marks found on pangolin scales can be matched to individuals and used as forensic evidence in court, halting supply chains of trafficked items.

My work will be part of the solution; I am currently working with the City of London Police to advise essential fingerprinting items needed on wildlife crime scenes, and my experiments can inform training given to investigators in the field. My procedures will be deployed in places where they are urgently needed to fight and prevent crime, and tackle global challenges often intertwined with pangolin poaching.

We’re excited to announce the winners of this year’s HSDTC Science Communication Competition!

Doctoral researchers at the four King’s health faculties were invited to submit a short ‘newspaper style’ article on their research topic. The article must be based on the research they are currently engaged with, or that the research group is doing, whether that be the whole project or one aspect of it. The article should be aimed at a non-specialist audience and be understandable to an interested member of the public.

The judges were looking for articles which:

  • are compelling to read and easily understandable
  • clearly explain the research being done
  • answer the question “why does this research matter?”
  • are worthy of publication in a national newspaper.

We were really lucky to have received 20 submissions, and we’ll showcase the winning pieces and other submissions in a few blog posts.

First Prize: Gorkem Ulkar, Faculty of Life Sciences & Medicine, Randall Centre for Cell & Molecular Biophysics

The secret signals of cancer

Cancer is a master of disguise. While we often think of it as a single lump that grows, its most dangerous ability is to spread. This process, called metastasis, is what makes cancer so lethal, transforming a localized disease into a widespread, systemic threat. But what if we could understand and stop cancer cells before they make their escape?

Scientists have long known that cancer spreads not just because of genetic mutations but also because of its environment: the physical world surrounding a tumour. Just like people respond to changes in their surroundings, cancer cells sense and react to the stiffness of the tissue around them. This stiffness can trigger changes in cell behaviour, making them more aggressive and more likely to spread. But how does this happen at a molecular level? That’s the question my research aims to answer.

Using cutting-edge imaging techniques, we are peering inside breast cancer cells as they move through different environments. We use a technique called Fluorescence Lifetime Imaging Microscopy (FLIM) to measure changes in the forces inside the cells, like tension in their membranes or shifts in the DNA packaging. By studying cells in 3D models that mimic real tumours, we can see how they respond to different levels of tissue stiffness. Are cells at the tumour’s edge, in contact with surrounding tissue, acting differently from those deeper inside? Does a stiffer environment push them toward becoming more invasive?

Early results show that changes in membrane tension and DNA structure happen together, suggesting that cancer cells coordinate their escape plan in response to mechanical forces. Understanding these signals could help us develop new therapies that target not just cancer’s genes but also its physical interactions.

This research matters because stopping metastasis could mean stopping cancer in its tracks. By uncovering how cancer senses and responds to its environment, we could pave the way for treatments that prevent it from spreading in the first place. In the fight against cancer, understanding its tricks is the first step to beating it.

Second Prize: Sara Gonzalez Ortega, Faculty of Life Sciences & Medicine, School of Cardiovascular and Metabolic Medicine & Sciences

Can we teach the heart to heal itself?

Every five minutes, someone in the UK suffers a heart attack. For many, the damage is irreversible. Once heart muscle cells die, they don’t grow back. But what if we could change that? Scientists are now exploring ways to reawaken the heart’s regenerative potential using tiny molecules called microRNAs (miRNAs).

A MAJOR UNMET NEED

Heart failure affects millions worldwide and remains a leading cause of death. Unlike some animals, such as zebrafish or newborn mice, which can regenerate heart tissue, the adult human heart lacks this ability. Once heart cells are lost, the heart forms scar tissue instead of regenerating, often leading to chronic heart failure. Current treatments manage symptoms but do not repair the damaged heart.

THE POWER OF microRNAs

MicroRNAs are small molecules that regulate gene activity. At Professor Mauro Giacca lab, scientists discovered that specific miRNAs—such as miR-199a-3p and miR-1825—can push heart cells to divide and regenerate, a groundbreaking finding that could revolutionize heart failure treatment.

DELIVERING A CURE

A key challenge is safely delivering these molecules to the heart. My research at King’s College London compares two methods:

  • Viral Vectors: Modified viruses introduce miRNA into heart cells for long-term effects.
  • Lipid Nanoparticles: Similar to the technology behind COVID-19 mRNA vaccines, these fat-based carriers deliver miRNAs safely and temporarily.

TESTING IN A “HEART IN A DISH”

To bridge the gap between lab research and human treatment, I use human myocardial slices—thin sections of living heart tissue obtained from surgical procedures such as myectomies or heart transplants. These otherwise discarded tissues continue beating in the lab, allowing realistic testing of miRNAs and delivery strategies. Using actual human heart tissue brings our findings much closer to real-world application.

A FUTURE WITHOUT HEART FAILURE?

The ability to regrow heart muscle cells could change the future of medicine. While we must ensure miRNAs don’t cause uncontrolled growth, this research brings us closer to a future where we can teach the heart to heal itself—offering hope to millions worldwide.

Third Prize: Tiffany Baptiste, Faculty of Life Sciences & Medicine, Biomedical Engineering and Imaging Sciences

One size fits all is convenient, but is it costing lives?

As cardiovascular disease remains the world’s top killer, scientists ask: can one-size-fits-all medicine keep up?

For decades, cardiovascular disease, the world’s leading cause of death, has been treated with a one-size-fits-all approach. But what if medicine could be as personalised as a tailored suit? Researchers at the Cardiac Electro-Mechanics Research Group (CEMRG) are working to make this possible using digital twins of the human heart.

Conditions such as heart failure and atrial fibrillation affect millions in the United Kingdom. Yet treatments still rely on broad clinical guidelines, even though no two hearts are exactly alike. Factors such as sex, age, ethnicity, and lifestyle can all influence how someone responds to therapy, but these differences are often overlooked.

Digital twins aim to change that. Using detailed, patient-specific data such as heart scans and electrical recordings taken in hospital, researchers can build a computer model of an individual’s heart that mimics its unique structure and function. These virtual hearts can be used to test treatments before they are applied to the real patient, offering a safer, smarter, and more personalised approach to care.

“Doctors often prescribe treatments based on past successes, but how do we know what is best for you?” asks Dr Ludovica Cicci, postdoctoral researcher at CEMRG. “Instead of trial and error, we can now test treatments virtually, reducing unnecessary procedures and improving outcomes.”

The hope is that these models will help doctors make better, more tailored decisions, transforming how we diagnose and treat heart disease.

However, the technology is not yet ready for everyday hospital use. Creating a true digital twin requires time and computing power to run the thousands of simulations needed to match model behaviour to real-life function. However, researchers are exploring how machine learning could streamline the process and make digital twins more practical for clinics.

“If no two people are the same, why should their treatments be?”, challenges Dr. Cicci. With continued innovation, digital twins of the heart could move us beyond one-size-fits-all healthcare, towards a future where every patient receives care that truly fits.

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