The MOSAIC Trial is open!


Welcome to our new blog to report news about MOSAIC (Motivating Structured walking Activity in Intermittent Claudication), a randomised controlled trial of a new treatment aimed at increasing walking in people with Intermittent Claudication (IC).

IC is a painful leg condition caused by Peripheral Arterial Disease (PAD). People with IC have narrowed or blocked arteries of their leg(s), reducing blood flow to the muscles, which causes cramping leg pain. Walking exercise improves walking ability and provides other health benefits in people with IC, such as improved quality of life. Unfortunately walking recommendations to offer at least 2 hours supervised exercise per week to people with IC are not being implemented as there are limited walking programmes offered by the NHS. Patients may benefit from support and guidance to increase their walking.

The MOSAIC Trial has been developed in consultation with patients and clinicians to evaluate a physiotherapy-led walking treatment. This provides patients with tools, such as a pedometer and walking diary, to help them increase their walking. The impact of MOSAIC treatment on walking ability will be compared with usual NHS care

The trial is now open and recruiting participants referred by the Vascular teams at Guy’s & St Thomas’ Hospitals, King’s College Hospital, Ashford & St Peter’s Hospitals and St George’s Hospital University Hospital NHS Foundation Trusts. We aim to recruit 192 patients in total and the main eligibility criteria are: 1) above 50 years of age, 2) confirmed IC caused by PAD, 3) not currently recommended for revascularisation or 4) no contraindications to walking exercise. Patients will not be able to take part if they have 1) unstable IC, 2) walking more than 90 minutes per week, 3) contraindications to walking exercise or 4) recent or upcoming participation in supervised exercise therapy.

We look forward to providing you with more updates about MOSAIC as the trial progresses. Please do contact us for more information or visit our trial website

Contact: Brittannia Abdul-Aziz, MOSAIC Research Assistant

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