The MOSAIC Trial showcased at the Society for Research in Rehabilitation (SRR) Winter Meeting, Bristol 6th February 2018

Melissa Galea Holmes, MOSAIC Trial Research Associate, presented at the SRR’s 40th Anniversary conference earlier this month. The presentation was titled ‘A brief physiotherapist-led behaviour change intervention to facilitate walking in older people with peripheral arterial disease: protocol for a randomised controlled trial’. Melissa also presented the outcomes of the preceding (feasibility) study that informed the development of the full MOSAIC Trial.

This was an important opportunity for the MOSAIC team to share their work with a wider multi-disciplinary audience.

Melissa comments: “Presenting on behalf of the MOSAIC Trial team at the 40th Anniversary of the SRR was a great privilege and a rich learning experience. Our presentations on the rehabilitation of people with IC were very well received. The feedback and interest of the audience in our research demonstrates the importance of our work to rehabilitation researchers and clinicians.”

Conference delegates were particularly interested in the MOSAIC Trial primary outcome, of whether MOSAIC will improve walking ability after three months in people with IC, compared to NHS Usual Care and the refinement of the MOSAIC intervention following the feasibility study. Melissa also discussed with attendees strategies which could be used to recruit hard to reach groups of people with high prevalence rates of peripheral arterial disease.

Overall, introducing MOSAIC Trial at this conference was a great success. The MOSAIC Trial is in the first months of enrolling participant’s at all four participating hospital sites, so this is an ideal time for this engagement.

Please contact us if you would like more information about the presentation or for a copy of the slides or poster. The abstract will be published shortly in the journal Clinical Rehabilitation.

The MOSAIC Trial is open!


Welcome to our new blog to report news about MOSAIC (Motivating Structured walking Activity in Intermittent Claudication), a randomised controlled trial of a new treatment aimed at increasing walking in people with Intermittent Claudication (IC).

IC is a painful leg condition caused by Peripheral Arterial Disease (PAD). People with IC have narrowed or blocked arteries of their leg(s), reducing blood flow to the muscles, which causes cramping leg pain. Walking exercise improves walking ability and provides other health benefits in people with IC, such as improved quality of life. Unfortunately walking recommendations to offer at least 2 hours supervised exercise per week to people with IC are not being implemented as there are limited walking programmes offered by the NHS. Patients may benefit from support and guidance to increase their walking.

The MOSAIC Trial has been developed in consultation with patients and clinicians to evaluate a physiotherapy-led walking treatment. This provides patients with tools, such as a pedometer and walking diary, to help them increase their walking. The impact of MOSAIC treatment on walking ability will be compared with usual NHS care

The trial is now open and recruiting participants referred by the Vascular teams at Guy’s & St Thomas’ Hospitals, King’s College Hospital, Ashford & St Peter’s Hospitals and St George’s Hospital University Hospital NHS Foundation Trusts. We aim to recruit 192 patients in total and the main eligibility criteria are: 1) above 50 years of age, 2) confirmed IC caused by PAD, 3) not currently recommended for revascularisation or 4) no contraindications to walking exercise. Patients will not be able to take part if they have 1) unstable IC, 2) walking more than 90 minutes per week, 3) contraindications to walking exercise or 4) recent or upcoming participation in supervised exercise therapy.

We look forward to providing you with more updates about MOSAIC as the trial progresses. Please do contact us for more information or visit our trial website

Contact: Brittannia Abdul-Aziz, MOSAIC Research Assistant